Born Mireille Aigroz in Toulon, France, she attended the Conservatory of Dramatic Arts (Conservatoire d'art dramatique de Toulon) in Toulon, and went to Paris in 1959. Her debut came in 1960 in Claude Barma's La Grande Brétèche. Her first leading role came in 1961 with Jean Prat's "Hauteclaire." She starred as Christine in Le Grand Blond avec une chaussure noire and Le retour du grand blond and alongside Alain Delon in several films: L'Homme pressé, Pouic-Pouic, Les Bons Vivants, Mort d'un pourri, Madly, Jeff, Les Seins de glace, Il était une fois un flic (fr), Borsalino and 2003's television series Frank Riva (fr).
In the 1980s her career was interrupted by open-heart surgery following a car accident, in which she was seriously injured, and her separation from Alain Delon after fifteen years together. She quit her film career, but returned to television in the 1990s.
In 2006, Jacques Chirac awarded Darc the Légion d'honneur.